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Selective Cell Elimination from Mixed 3D Culture Using a Near Infrared Photoimmunotherapy Technique
Published on: March 14, 2016
Human IRGM induces autophagy to eliminate intracellular mycobacteria
Sudha B Singh1, Alexander S Davis, Gregory A Taylor
1Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Abstract:
Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.
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