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Updated: Aug 6, 2026

Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
A role for pituitary adenylate cyclase activating polypeptide (PACAP) in detrusor hyperreflexia after spinal cord
Peter Zvara1, Karen M Braas, Victor May
1University of Vermont College of Medicine, Department of Neurology, D411 Given Building, Burlington, VT 05405, USA.
Abstract:
Intrathecal administration of the PAC1 receptor antagonist, PACAP6-38 (10 nM), significantly (P < or = 0.05) reduced intermicturition, threshold and micturition pressures in chronic (3-6 weeks) spinal cord injured rats but intravesical administration (100-300 nM) was without effect. Intrathecal PACAP6-38 reduced the number and amplitude of nonvoiding bladder contractions observed after spinal cord injury (SCI). PACAP may contribute to detrusor hyperreflexia induced by SCI and PACAP antagonists may be a novel approach to reduce detrusor hyperreflexia after SCI.
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