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Related Experiment Videos

The effect of type 2 diabetes on diastolic function.

James C Baldi1, James L Aoina, Gillian A Whalley

  • 1Department of Sport and Exercise Science, The University of Auckland, Auckland, New Zealand. j.baldi@auckland.ac.nz

Medicine and Science in Sports and Exercise
|August 5, 2006
PubMed
Summary

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Type 2 diabetes impairs early diastolic relaxation and increases left ventricular filling pressure in sedentary overweight individuals, independent of age and body composition. This suggests a direct effect of diabetes on heart function.

Area of Science:

  • Cardiology
  • Diabetology
  • Echocardiography

Background:

  • Type 2 diabetes is a growing global health concern.
  • Obesity and sedentary lifestyles are common comorbidities.
  • Diastolic dysfunction is a potential complication of diabetes.

Purpose of the Study:

  • To investigate diastolic function in sedentary overweight individuals with type 2 diabetes.
  • To compare diastolic function between diabetic and non-diabetic subjects with similar demographics.
  • To determine if diabetes independently affects diastolic function.

Main Methods:

  • Utilized mitral valve pulsed Doppler echocardiography and tissue Doppler imaging (TDI).
  • Assessed left ventricular structure and diastolic function in two groups: type 2 diabetes (N=13) and matched controls (N=15).

Related Experiment Videos

  • Identified pseudonormal filling using preload reduction and TDI.

    • Main Results:

    • Early diastolic relaxation (E' and E'/A') was significantly reduced in type 2 diabetic subjects.
    • Left ventricular filling pressure (E/E') was elevated in the type 2 diabetes group.
    • Traditional Doppler parameters and proportions of diastolic impairment/pseudonormal filling did not differ significantly.

    Conclusions:

    • Type 2 diabetes negatively impacts diastolic function.
    • This effect appears independent of age and body composition.
    • Diabetes directly influences cardiac diastolic performance.