Related Experiment Video
Updated: Aug 6, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
[Features of a cytokine profile in patients with chronic glomerulonephritis with progressive chronic renal failure]
Aim:
To specify the cytokine profile in chronic glomerulonephritis (CGN) with aggravating renal function, to assess prognostic value of some cytokines in development of CGN in these patients.
Material And Methods:
Indices of the cytokine profile were followed up in 56 CGN patients with nephrotic syndrome and arterial hypertension and compared in those patients who developed CGN for 2 years (group 2) versus patients with intact renal function (group 1).
Results:
Serum levels of IL-1beta and TNF-alpha were maximal in CGN patients with aggravating renal function. Such patients had a low concentration of serum IL-1beta receptors antagonists. Severity of proteinurea correlated with serum level of TNF-alpha. If the latter was higher than 120 pg/ml, there was a high probability of CRF development within 2 years.
Conclusion:
Pathogenesis of CRF in CGN is associated with proinflammatory cytokines, especially TNF-alpha. Its serum concentration can be used for evaluating risk of renal function deterioration.
Related Concept Videos
Acute Kidney Injury III: Clinical Manifestations
Diabetic Nephropathy
Nephrotic Syndrome II : Assessment and Medical Management
Chronic Inflammation: Introduction
Acute Kidney Injury I: Introduction
Acute Kidney Injury IV: Diagnostic Studies and Prevention