Search research articles

Search research articles

Related Experiment Videos

Microemulsions with timolol as potential eye drops.

I Malina¹, A Radomska-Soukharev

¹Department of Pharmaceutical Technology, Karol Marcinkowski University of Medical Sciences, 6, Grunwaldzka Str, 60-780 Poznan, Poland. imalina@amp.edu.pl

|August 8, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Chemical stability of lipid excipients in SLN-production of test formulations, characterisation and short-term stability.

Die Pharmazie·2006

See all related articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Stable timolol microemulsions, both oil-in-water and water-in-oil, were successfully prepared and sterilized. These ophthalmic formulations maintained their physical integrity and met all requirements for eye drops after three months of storage.

Area of Science:

Ophthalmic drug delivery
Physical chemistry of emulsions

Background:

Timolol is a widely used beta-blocker for treating glaucoma.
Developing stable and sterile ophthalmic formulations is crucial for effective drug delivery.

Purpose of the Study:

To prepare and characterize stable oil-in-water (o/w) and water-in-oil (w/o) microemulsions containing timolol.
To evaluate the impact of different sterilization methods and storage conditions on microemulsion stability.

Main Methods:

Preparation of o/w and w/o microemulsions with timolol.
Sterilization via autoclaving and sterile filtering (Polish Pharmacopeia V).
Assessment of physical parameters (density, viscosity, refractive index, surface tension, pH, osmotic tension) at 25°C and 5°C for three months.

Related Experiment Videos

Main Results:

Stable o/w and w/o microemulsions containing timolol were successfully obtained.
Both sterilization methods were compatible with the microemulsion formulations.
All tested physical parameters remained within acceptable limits for ophthalmic use throughout the study period.

Conclusions:

Sterilized timolol microemulsions (o/w and w/o) exhibit excellent physical stability.
These microemulsions meet the stringent requirements for ophthalmic preparations, indicating their potential for clinical use.