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Updated: Aug 6, 2026

NMR-Based Fragment Screening in a Minimum Sample but Maximum Automation Mode
Published on: June 4, 2021
Nuclear magnetic resonance in target profiling and compound file enhancement
Chaohong Sun1, Philip J Hajduk
1Abbott Laboratories, R46Y, AP-IO, 100 Abbott Park Road, Abbott Park, IL 60064-3500, USA. chaohong.sun@abbott.com
Abstract:
Nuclear magnetic resonance (NMR) has matured as an important tool in drug discovery and development, with firm establishment of its roles in lead generation and optimization through application of NMR-based fragment screening and structure-based drug design. Besides these applications, NMR technology has expanded to make contributions both earlier and later in the drug discovery process. This review will focus on the impact of NMR in the early stages of drug discovery, in particular in characterizing the viability of targets for further discovery exercises and improving high-throughput screening through compound file-enhancement initiatives.
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