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Apomorphine in dopaminergic therapy.

J Anand Subramony1

  • 1ALZA Corporation, 1900 Charleston Road, Mountain View, California 94043, USA. asubramo@alzus.jnj.com

Molecular Pharmaceutics
|August 8, 2006
PubMed
Summary

Apomorphine, a dopamine agonist, effectively treats Parkinson's disease (PD) by stimulating brain receptors. (R)-Apomorphine provides rapid relief for unpredictable "on-off" periods, improving motor control.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder impacting motor function.
  • Levodopa (L-dopa) is a primary treatment, but its efficacy can fluctuate.
  • Managing unpredictable "on-off" periods is a significant challenge in PD therapy.

Observation:

  • Apomorphine, structurally similar to dopamine, acts as a D1 and D2 receptor agonist.
  • (R)-Apomorphine is the therapeutically active stereoisomer.
  • Apomorphine demonstrates clinical efficacy comparable to L-dopa.

Findings:

  • (R)-Apomorphine serves as an effective rescue medication for the wearing-off effect of L-dopa.
  • Its rapid action helps control unpredictable "on-off" fluctuations in PD patients.
  • Key structural features contribute to apomorphine's therapeutic activity.

Implications:

  • Apomorphine offers a rapid therapeutic option for managing motor fluctuations in Parkinson's disease.
  • Understanding its chemical stability and exploring alternative delivery methods are crucial for optimizing treatment.
  • This review highlights apomorphine's historical development and therapeutic potential in PD management.

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