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Related Experiment Videos

Risperidone-induced hyperprolactinemia in adolescents: A case series.

Subramoniam Madhusoodanan1, Despina Moise

  • 1Department of Psychiatry, State University of New York, Health Science Center at Brooklyn and St. John's Episcopal Hospital, Far Rockaway, NY 11691, USA. sdanan@ehs.org

The Journal of Clinical Psychiatry
|August 8, 2006
PubMed
Summary

Risperidone treatment in adolescents can cause elevated prolactin levels (hyperprolactinemia). Discontinuing risperidone and switching to other antipsychotics normalized prolactin and resolved symptoms in a case study.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Pharmacology
  • Endocrinology

Background:

  • Risperidone is an atypical antipsychotic used in adolescent psychiatric care.
  • Hyperprolactinemia is a known side effect of some antipsychotics, potentially leading to serious complications.
  • Adolescents may be particularly susceptible to risperidone-induced hyperprolactinemia.

Observation:

  • Three adolescent patients with psychiatric diagnoses developed hyperprolactinemia with clinical symptoms during risperidone treatment.
  • Symptoms of hyperprolactinemia included [specific symptoms if available in text, otherwise omit].

Findings:

  • Discontinuation of risperidone led to the normalization of prolactin levels in all three patients.
  • Clinical symptoms associated with hyperprolactinemia resolved within two weeks of risperidone tapering and cessation.

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  • Switching to alternative atypical antipsychotics was part of the management strategy.

    • Implications:

    • Hyperprolactinemia due to risperidone is a significant concern in adolescent patients.
    • Early recognition and management, including switching to prolactin-sparing agents, are crucial.
    • This side effect can have serious complications if not addressed promptly.