Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Crossing cellular barriers using dendrimer nanotechnologies.

Mohammad Najlah1, Antony D'Emanuele

  • 1School of Pharmacy and Pharmaceutical Sciences, University of Central Lancashire, Preston, Lancashire PR1 2HE, UK.

Current Opinion in Pharmacology
|August 8, 2006
PubMed
Summary

Dendrimers, highly uniform polymers, are effective intracellular drug carriers. New dendrimer systems can bypass efflux transporters, improving drug delivery across cellular barriers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Solid Dispersions to Enzyme-Responsive Nanocarriers: Whey Protein Isolate Nanoparticles for Enhanced Curcumin Encapsulation and Targeted Delivery.

Pharmaceutics·2026
Same author

Spray-dried zinc-alginate microparticles for antibiotic removal from water: a promising approach to mitigate antibiotic resistance.

Pharmaceutical development and technology·2026
Same author

The Use of Tele-Music Interventions in Supportive Cancer Care: A Systematic Review.

Brain sciences·2025
Same author

Correction: Dumbuya et al. Exploring Disulfiram's Anticancer Potential: PLGA Nano-Carriers for Prolonged Drug Delivery and Potential Improved Therapeutic Efficacy. <i>Nanomaterials</i> 2024, <i>14</i>, 1133.

Nanomaterials (Basel, Switzerland)·2025
Same author

Targeting Fear of Cancer Recurrence with Internet-Based Emotional Freedom Techniques (iEFT) and Mindfulness Meditation Intervention (iMMI) (BGOG-gyn1b/REMOTE).

Brain sciences·2025
Same author

Sugar-Linked Diethyldithiocarbamate Derivatives: A Novel Class of Anticancer Agents.

International journal of molecular sciences·2025

Area of Science:

  • Polymer Chemistry
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Dendrimers are well-defined polymers with uniform molecular structures.
  • They possess diverse pharmaceutical applications.
  • Recent research highlights their potential as intracellular drug carriers.

Purpose of the Study:

  • To explore the utility of dendrimers as intracellular drug delivery vehicles.
  • To investigate the ability of dendrimers to overcome efflux transporter mechanisms.
  • To introduce novel dendrimer-based systems for enhanced drug transport across cellular barriers.

Main Methods:

  • Characterization of dendrimer structure and properties.
  • In vitro studies assessing cellular uptake and intracellular drug release.

Related Experiment Videos

  • Evaluation of dendrimer interaction with efflux transporters.

    • Main Results:

    • Dendrimers demonstrate high molecular uniformity and low polydispersity.
    • They effectively function as intracellular carriers for various drugs.
    • Dendrimers exhibit the capability to bypass common efflux transporters.

    Conclusions:

    • Dendrimers are promising candidates for advanced drug delivery systems.
    • Their unique structure facilitates efficient intracellular transport.
    • Next-generation dendrimer-based systems offer potential for overcoming cellular barriers in drug delivery.