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Related Experiment Videos

Intradermal positivity after negative prick testing for inhalants.

Shawn P McKay1, Danny Meslemani, Robert J Stachler

  • 1Department of Otolaryngology-Head and Neck Surgery, Wayne State University, 4201 St. Antoine, Detroit, MI 48202, USA.

Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
|August 8, 2006
PubMed
Summary

Positive intradermal allergy tests are common after negative skin prick tests, especially for dust mites. Further research is needed to understand the clinical significance of these findings.

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Area of Science:

  • Allergy and Immunology
  • Dermatology

Background:

  • Skin prick testing (SPT) is a primary method for diagnosing inhalant allergies.
  • False-negative results in SPT can lead to underdiagnosis and undertreatment of allergic conditions.

Purpose of the Study:

  • To investigate the frequency of positive intradermal tests following negative skin prick tests for 24 common inhalant allergens.
  • To identify specific allergens that frequently elicit positive intradermal responses despite negative SPT results.

Main Methods:

  • A retrospective study analyzing patient charts from a 3-year period.
  • Modified quantitative testing (MQT) was employed, starting with Multi-Test II for skin prick tests.
  • Patients with negative wheal responses to specific allergens underwent subsequent intradermal testing with a 1:500 weight:volume dilution.

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Main Results:

  • Out of 133 patients tested for 24 antigens, a significant incidence of positive intradermal tests was observed after negative SPTs.
  • Dermatophagoides pteronyssinus and Dermatophagoides farinae showed the highest incidence of positive intradermal tests at 26.67%.
  • Other allergens with elevated positive intradermal rates included fusarium, cockroach, cocklebur, rough marsh elder, and ragweed (16%-19%).

Conclusions:

  • Positive intradermal test responses following negative skin prick tests are a common occurrence.
  • The clinical significance and generalizability of these findings require further investigation.