Related Experiment Video
Updated: Aug 6, 2026

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Topical otic antibiotics: clinical cochlear ototoxicity and cost consideration
Leonard P Berenholz1, John M Burkey, Tonia L Farmer
1Lippy Group for Ear, Nose and Throat, 3893 East Market Street, Warren, OH 44484, USA. lenb344@adelphia.net
Objective:
Determine the incidence of clinical cochlear ototoxicity in routine use of Cortisporin after ventilation tube placement. Cost differential between use of Cortisporin and fluoroquinolone agents was evaluated.
Methods:
A retrospective review of 500 patients was performed. Cortisporin otic suspension was used for 5 days following ventilation tube insertion.
Results:
Testing following surgery indicated a sensorineural hearing loss (SNHL) in 19 (2.1%) ears. The SNHL existed prior to the surgery and there was no deterioration in the hearing postoperatively. The total cost for our study group who used Cortisporin was $15,500. If Floxin had been prescribed the cost would have been $45,000. Had Ciprodex been prescribed, the cost would have been $49,500.
Conclusion:
Our study demonstrates no clinical cochlear ototoxicity in children who received Cortisporin following ventilation tube placement. The cost differential for prescribing fluoroquinolone drops is significant.
Ebm Rating:
C-4.
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