Related Experiment Video

Updated: Aug 5, 2026

Heterotopic Heart Transplantation in Mice
23:43

Heterotopic Heart Transplantation in Mice

Published on: July 19, 2007

Successful combined heart and kidney transplantation in a patient with sickle-cell anemia

Vincent Audard1, Philippe Grimbert, Matthias Kirsch

  • 1Department of Nephrology and Transplantation, Henri Mondor Hospital, Université Paris XII, Créteil, France.

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|August 8, 2006
PubMed

Insights

Dual-organ transplantation, combining heart and kidney, is a feasible treatment for sickle-cell disease (SCD) complications. This case study highlights successful management and positive outcomes for SCD patients requiring combined transplants.

Area of Science:

  • Cardiology
  • Nephrology
  • Hematology

Background:

  • Sickle-cell disease (SCD) can lead to end-stage heart and renal failure.
  • Management strategies for dual-organ transplantation in SCD patients are not well-established.

Observation:

  • A 33-year-old male with homozygous SCD underwent combined heart and kidney transplantation due to end-stage organ failure.
  • The patient received pre-operative blood transfusions and moderate hypothermic cardiopulmonary bypass.
  • Post-operative management included monitoring for rejection and SCD complications.

Findings:

  • The combined heart and kidney transplant was successful with limited peri-operative complications.
  • The patient experienced one episode of acute heart rejection within 6 months, without renal rejection.
  • At 18 months post-surgery, the patient maintained preserved allograft function, with asymptomatic renal artery stenosis and no vaso-occlusive crises or septic events.
  • SCD management involved periodic transfusions.

Implications:

  • Combined heart and kidney transplantation is a viable option for select SCD patients.
  • Meticulous peri- and post-operative care is crucial for successful outcomes in these complex cases.
  • This approach offers a potential therapeutic avenue for SCD patients with multi-organ failure.

More Related Videos

Optimization of the Cuff Technique for Murine Heart Transplantation14:01

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology08:15

Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology

Published on: July 3, 2026

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...