Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Understanding eating disorders.

Per Södersten1, Cecilia Bergh, Michel Zandian

  • 1Karolinska Institutet, Section of Applied Neuroendocrinology, Center for Eating Disorders, AB Mando, Novum, S-141 57 Huddinge, Sweden. per.sodersten@ki.se

Hormones and Behavior
|August 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Cold-Water Immersion on Post-Match Recovery in Trained Soccer Players: A Systematic Review and Meta-Analysis.

Scandinavian journal of medicine & science in sports·2026
Same author

Micro-encapsulation differentially impacts probiotic effects on brain structure and function in an elderly population - A randomised placebo-controlled trial.

Brain, behavior, and immunity·2025
Same author

Patient-reported physical activity, pain, and fear of movement after cardiac surgery: a descriptive cross-sectional study.

Scandinavian cardiovascular journal : SCJ·2024
Same author

The Effect of Whole-Diet Interventions on Memory and Cognitive Function in Healthy Older Adults - A Systematic Review.

Advances in nutrition (Bethesda, Md.)·2024
Same author

Pleiotropic Effects of Influenza Vaccination.

Vaccines·2023
Same author

Eating Behavior and Satiety With Virtual Reality Meals Compared With Real Meals: Randomized Crossover Study.

JMIR serious games·2023

Eating disorders stem from starvation responses, not just poor eating. A new treatment focusing on normal eating, controlled activity, and external heat shows effectiveness in trials.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Evolutionary Biology

Background:

  • Eating disorders have poor treatment outcomes, suggesting current approaches are insufficient.
  • Symptoms may be secondary to starvation and disordered eating, driven by evolved neuroendocrine responses.
  • Starvation triggers adaptive neuroendocrine changes facilitating behavioral flexibility, not just altered food intake.

Purpose of the Study:

  • To propose a neurobiologically realistic explanation for the development and maintenance of eating disorders.
  • To introduce a novel treatment framework based on understanding these neurobiological mechanisms.
  • To evaluate the efficacy of this new treatment method.

Main Methods:

  • Conceptualizing eating disorders as adaptive responses to starvation, involving reward system activation and conditioning.

Related Experiment Videos

  • Implementing a treatment protocol that includes teaching normal eating patterns, controlling physical activity, and providing external heat.
  • Conducting a randomized controlled trial to assess treatment effectiveness.

    • Main Results:

    • The proposed neurobiological model offers a parsimonious explanation for eating disorder pathology.
    • The novel treatment method, based on this framework, demonstrated effectiveness in a randomized controlled trial.
    • Key components of the treatment include behavioral normalization and environmental regulation.

    Conclusions:

    • Eating disorders may be maintained by neural mechanisms related to reward and attention, triggered by reduced food intake.
    • A treatment approach addressing these underlying mechanisms, alongside behavioral and environmental factors, is effective.
    • This research offers a new perspective on eating disorder etiology and treatment.