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Updated: Aug 6, 2026
Impact of Intracardiac Neurons on Cardiac Electrophysiology and Arrhythmogenesis in an Ex Vivo Langendorff System
Published on: May 22, 2018
Rostral parvicellular reticular formation neurons projecting to rostral ventrolateral medulla receive cardiac inputs
Diana Oskutyte1, Ken'ichi Ishizuka, Yoshihide Satoh
1Department of Physiology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Niigata 951-8580, Japan.
Abstract:
The rostral parvicellular reticular formation (rRFp) was explored electrophysiologically in urethane-chloralose anesthetized rats. Spontaneously-active neurons that exhibited a pulse-related activity were recorded and tested for their projections to the rostral ventrolateral medulla (RVLM). About one-third (10/29) of the rRFp neurons that exhibited a pulse-related activity were antidromically activated by RVLM stimulation with conduction velocities between 0.2-4.4m/s and fell within the B and C fibre range. A majority (8/10) of these neurons had a low (<10spikes/s) mean firing rate, whereas a small proportion (2/10) had a high (>15spikes/s) mean firing rate. These findings suggest a direct pathway from the rRFp to the RVLM and suggest that neurons projecting to the RVLM receive cardiac inputs and can modulate RVLM neuronal activity.
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