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Anthracene based base-discriminating fluorescent oligonucleotide probes for SNPs typing: synthesis and photophysical

Yoshio Saito1, Kaori Motegi, Subhendu Sekhar Bag

  • 1Department of Materials Chemistry and Engineering, School of Engineering, Nihon University, Japan. saitoy@chem.ce.nihon-u

Bioorganic & Medicinal Chemistry
|August 8, 2006
PubMed

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...