Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Precious metal economy.

Sabeeha S Merchant1, Alvaro Sagasti

  • 1Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, USA.

Cell Metabolism
|August 8, 2006
PubMed
Summary

Zebrafish models reveal how maternal nutrition impacts copper deficiency diseases like Menkes disease. This study details temporal and dosage-dependent effects on embryo development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioengineered algal lipids enriched in structured medium- and long-chain triacylglycerols, linoleate, and <i>sn</i>-2 palmitate for human milk fat substitutes.

bioRxiv : the preprint server for biology·2026
Same author

Investigating overflow metabolism in heterotrophic cultures of the green alga Chromochloris zofingiensis.

Metabolic engineering·2026
Same author

Mono-mix strategy enables comparative proteomics of a cross-kingdom microbial symbiosis.

PloS one·2026
Same author

Acclimation to high and low diurnal light is flexible in <i>Chlamydomonas reinhardtii</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Genetically pliable green algae for bioproduction of modified fatty acids, nutritional therapeutic oils, and biopharmaceuticals.

Current opinion in biotechnology·2025
Same author

Hidden diversity: Transcriptomic and photosynthetic variation among common 'wild type' Chlamydomonas strains.

The Plant journal : for cell and molecular biology·2025

Area of Science:

  • Developmental Biology
  • Genetics
  • Nutritional Science

Background:

  • Zebrafish (Danio rerio) are increasingly utilized as a model organism for human diseases.
  • Menkes disease is a genetic disorder affecting copper utilization in humans.

Discussion:

  • Mendelsohn et al. (2006) present a zebrafish model for Menkes disease.
  • The study employed genetic and chemical screens to investigate copper metabolism.
  • Maternal nutrition's influence on embryonic development was a key focus.

Key Insights:

  • The research highlights the critical role of maternal nutrition in embryonic development related to copper.
  • A hierarchy of temporal and dosage-dependent phenotypes associated with copper nutrition was elucidated.
  • This work provides insights into the complex mechanisms of copper homeostasis and its impact on development.

Outlook:

  • Further research can explore targeted nutritional interventions for copper-related disorders.
  • The zebrafish model offers a platform for screening potential therapeutic compounds.
  • Understanding these developmental impacts can inform strategies for managing genetic metabolic diseases.

Related Experiment Videos