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Updated: Aug 6, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
Published on: April 3, 2017
Dirty dealing: hepatic vagal afferents reshuffle fat distribution
1Albert Einstein College of Medicine of Yeshiva University, Diabetes Research and Training Center, Department of Medicine, 1300 Morris Park Avenue, Golding 501, Bronx, New York 10463, USA.
Abstract:
To evaluate the role of hepatic peroxisome-proliferator-activated receptor (PPAR) gamma 2 in the control of energy balance, Uno and colleagues examined the metabolic effects of overexpression of PPAR gamma 2 selectively in mouse and rat liver. Mice demonstrated a surprising degree of hepatic steatosis accompanied by significant reductions in peripheral adiposity. This crosstalk between liver and adipose tissue appears to be mediated by both the sensory component of the hepatic vagus nerve and sympathetic efferents. These data suggest a novel hepatic-adipose neuraxis that regulates the distribution of stored fat.
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