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Updated: Jul 13, 2026
11:28
Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
HIV/AIDS epidemiology, pathogenesis, prevention, and treatment
Viviana Simon1, David D Ho, Quarraisha Abdool Karim
1Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY, USA. viviana.simon@mssm.edu
Lancet (London, England)
|August 8, 2006
Summary
The human immunodeficiency virus type 1 (HIV-1) pandemic remains a global health crisis. While treatments manage AIDS, a cure or vaccine for HIV-1 is still needed, especially in high-burden regions.
Area of Science:
- Global Health
- Infectious Diseases
- Virology
Background:
- The human immunodeficiency virus type 1 (HIV-1) pandemic presents as a complex global public health crisis.
- Despite advancements in understanding HIV-1 replication, pathogenesis, and transmission, a definitive cure or protective vaccine remains elusive.
- Antiretroviral therapy has shifted Acquired Immunodeficiency Syndrome (AIDS) to a manageable chronic condition in certain areas, but this progress is not universal.
Purpose of the Study:
- To provide a comprehensive update on the epidemiology of HIV-1.
- To review current knowledge on HIV-1 pathogenesis and transmission dynamics.
- To summarize advancements in HIV-1 treatment and prevention strategies.
Main Methods:
- Review of current epidemiological data on HIV-1.
- Analysis of recent research on HIV-1 pathogenesis.
- Synthesis of information on antiretroviral treatment efficacy and prevention interventions.
Main Results:
- HIV-1 epidemics are diverse and vary significantly between and within countries.
- Understanding of viral replication, manipulation, and latency has improved.
- Antiretroviral treatment has successfully managed AIDS in many settings, but disparities persist globally.
Conclusions:
- The HIV-1 pandemic requires ongoing research and tailored interventions for diverse global epidemics.
- Equitable access to effective treatment and prevention is crucial to address the disproportionate burden of HIV-1 in certain regions.
- Continued efforts are needed to develop a cure and a protective vaccine for HIV-1.
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