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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
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MET expression in sporadic renal cell carcinomas

Jong Sun Choi1, Mi-Kyung Kim, Jin Won Seo

  • 1Department of Pathology, Cheil General Hospital, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Seoul, Korea.

Journal of Korean Medical Science
|August 8, 2006
PubMed

Insights

The MET proto-oncogene is highly expressed in papillary and collecting duct renal cell carcinoma (RCC), aiding in diagnosis. MET expression in clear cell RCC indicates aggressive features.

Area of Science:

  • Oncology
  • Molecular Pathology
  • Urologic Pathology

Background:

  • Germline mutations in the MET proto-oncogene are established markers for hereditary papillary renal cell carcinoma (RCC).
  • The expression and clinical significance of MET protein in sporadic RCC remain underexplored.

Purpose of the Study:

  • To investigate the expression patterns of MET protein in various subtypes of renal neoplasms.
  • To determine the clinical significance of MET expression in sporadic renal cell carcinoma, particularly clear cell RCC.

Main Methods:

  • Immunohistochemistry was employed to assess MET expression.
  • The study analyzed 182 cases, including 145 RCCs, 25 urothelial carcinomas of the renal pelvis, and 12 oncocytomas.

Main Results:

  • Diffuse and strong MET expression was observed in 90% of papillary RCC, all collecting duct carcinomas, and 92% of urothelial carcinomas of the renal pelvis.
  • Clear cell RCC, chromophobe RCC, and oncocytomas showed negative or focal MET expression.
  • In clear cell RCC, MET expression correlated with high nuclear grade, infiltrative growth, necrosis, papillary architecture, sarcomatoid features, pelvic/ureteral involvement, calyceal involvement, and lymphatic invasion.

Conclusions:

  • Diffused and strong MET expression can help differentiate papillary RCC and collecting duct carcinoma from other RCC subtypes with tubular or papillary growth.
  • MET expression in clear cell RCC may serve as a biomarker for aggressive clinicopathological features.

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