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Updated: Aug 6, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Avoiding misclassification bias with the traditional Charnley classification: rationale for a fourth Charnley class
Insights
Patients with unilateral total hip arthroplasty (THA) and hip disease experience reduced walking ability. A new classification distinguishes these patients from those with bilateral THA, who maintain good mobility.
Area of Science:
- Orthopedic surgery
- Biomedical engineering
- Rehabilitation medicine
Background:
- Long-term total hip arthroplasty (THA) follow-up shows walking capacity decline in Charnley class B post-surgery.
- This decline may be linked to specific patient subgroups within Charnley class B.
Purpose of the Study:
- To investigate the distinct walking capacities of patients with unilateral THA and contralateral hip disease versus those with bilateral THA.
- To propose a modified Charnley classification system to differentiate these patient groups.
Main Methods:
- Prospective evaluation of 15,160 patients with 35,773 follow-ups over 10 years.
- Categorization into four classes using a modified Charnley classification.
- Annual analysis of ambulation duration (>60 min).
Main Results:
- Charnley class B comprises two distinct groups: unilateral THA with contralateral disease (underaverage walking capacity, declining ambulation) and bilateral THA (stable, overaverage walking capacity).
- Patients with bilateral THA demonstrated walking capacities similar to Charnley class A.
Conclusions:
- The traditional Charnley class B is heterogeneous regarding walking capacity.
- A proposed extended classification, including a new 'BB' class for bilateral THA, better reflects patient mobility and outcomes.
- This refined classification aids in understanding long-term THA patient outcomes.
Abstract:
Long-term follow up of patients with total hip arthroplasty (THA) revealed a marked deterioration of walking capacities in Charnley class B after postoperative year 4. We hypothesized that a specific group of patients, namely those with unilateral hip arthroplasty and an untreated but affected contralateral hip was responsible for this observation. Therefore, we conducted a study taking into consideration the two subclasses that make up Charnley class B: patients with unilateral THA and contralateral hip disease and patients with bilateral THA. A sample of 15,160 patients with 35,773 follow ups that were prospectively collected over 10 years was evaluated. The sample was categorized into four classes according to a new modified Charnley classification. Annual analyses of the proportion of patients with ambulation longer than 60 min were conducted. The traditionally labeled Charnley class B consists of two very different patient groups with respect to their walking capacities. Those with unilateral THA and contralateral hip disease have underaverage walking capacities and a deterioration of ambulation beginning 3 to 4 years after surgery. Those with bilateral THA have stable overaverage walking capacities similar to Charnley class A. An extension of the traditional Charnley classification is proposed, taking into account the two different patient groups in Charnley class B. The new fourth Charnley class consists of patients with bilateral THA and was labeled BB in order to express the presence of two artificial hip joints and to preserve the traditional classification A through C.
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