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Statistical considerations for noninferiority/equivalence trials in vaccine development

W W B Wang1, D V Mehrotra, I S F Chan

  • 1Clinical Biostatistics, Merck Research Laboratories, North Wales, Pennsylvania 19454, USA. William_Wang@Merck.Com

Journal of Biopharmaceutical Statistics
|August 9, 2006
PubMed
Summary

Noninferiority and equivalence designs in vaccine trials demonstrate new vaccines are as effective as existing ones. These statistical methods are crucial for vaccine development, ensuring efficacy while offering benefits like improved safety or easier administration.

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