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Use of proton pump inhibitors during pregnancy and breastfeeding
Alejandro A Nava-Ocampo1, Elvia Y Velázquez-Armenta, Jung-Yeol Han
1Hospital for Sick Children in Torinto, Ont.
Question:
A 36-year-old pregnant patient has symptoms of peptic disease. Treatment with diet and lifestyle modifications and also antacids has given her little relief. If she were not pregnant, I would prescribe a proton pump inhibitor (PPI) for her. She is now 4 weeks pregnant, and I need to determine whether PPIs are safe during pregnancy.
Answer:
Data currently available suggest that omeprazole is not teratogenic in humans. While information on other PPIs is limited, a systematic review of the evidence suggests that they are also not teratogenic.
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