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Updated: Aug 6, 2026

Lipid-Protein Membrane Structure-Function Characterization using Droplet Interface Bilayers
Published on: June 12, 2026
Bias-dependent admittance in hybrid bilayer membranes
Vesselin Nikolov1, Aleksandar Radisic, Kalina Hristova
1Department of Materials Science and Engineering, and Institute of NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Abstract:
Artificial bilayer membranes provide a platform for bioelectronic devices based on their structural, sensing, and transport functions. In this letter, we report on the impedance response of an engineered membrane with a lower leaflet of octadecanethiol on gold and an outer leaflet of dioleoylphosphatidylcholine with the monomeric channel protein gramicidin. This hybrid bilayer exhibits an electrical response analogous to a solid-state diode: the admittance is very low (<10(-)(7) Omega(-)(1) cm(-)(2)) over a wide potential range but increases exponentially at negative potentials.
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