Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrasonically induced opening of polyelectrolyte microcontainers.

Dmitry G Shchukin1, Dmitry A Gorin, Helmuth Möhwald

  • 1Max-Planck Institute of Colloids and Interfaces, D14424 Potsdam, Germany. Dmitry.Shchukin@mpikg.mpg.de

Langmuir : the ACS Journal of Surfaces and Colloids
|August 9, 2006
PubMed
Summary

Ultrasonic treatments effectively break down polyelectrolyte capsules, releasing contents. Magnetite nanoparticles enhance this release and allow targeted delivery for medical applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Liquid metal capsules for autonomic thermal energy control.

RSC advances·2026
Same author

Application of iron oxide nanoparticles in liver drug delivery: insights into biodegradation and toxicity at cellular, tissue, and organ levels.

Expert opinion on drug delivery·2026
Same author

Photoacoustic monitoring of freezing-induced loading and freeze-casting processes.

Biomedical optics express·2025
Same author

Direct insights into synthesis, protein integrity, and blood microrheology of albumin microbubbles.

Acta biomaterialia·2025
Same author

Environmentally responsive semi-interpenetrating network microcapsules with enhanced stability for corrosion protection.

Materials horizons·2025
Same author

Ultrasmall maghemite nanoparticles as MRI contrast agent: Unique combination of aggregation stability, low toxicity, and tumor visualization.

Nanomedicine : nanotechnology, biology, and medicine·2025

Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Polyelectrolyte capsules are versatile for drug delivery.
  • Controlled release mechanisms are crucial for therapeutic efficacy.
  • Integrating magnetic nanoparticles offers enhanced control.

Purpose of the Study:

  • To investigate ultrasonic effects on polyelectrolyte capsule integrity.
  • To evaluate the role of magnetite nanoparticles in release kinetics.
  • To assess the medical applicability of ultrasonically triggered release.

Main Methods:

  • Fabrication of poly(allylamine)/poly(styrene sulfonate) and Fe(3)O(4)/polyelectrolyte capsules.
  • Application of ultrasonic treatments with varying intensity and duration.

Related Experiment Videos

  • Analysis of capsule integrity and encapsulated material release.

    • Main Results:

    • Ultrasonic treatment rapidly destroys capsule shells, releasing contents within seconds.
    • Magnetite nanoparticles significantly boost ultrasonically stimulated release efficiency.
    • Magnetic targeting enables site-specific delivery prior to sonication.

    Conclusions:

    • Ultrasonic treatment is a viable method for rapid polyelectrolyte capsule disruption.
    • Magnetite-enhanced capsules offer controlled and targeted drug delivery potential.
    • The technology shows promise for medical applications requiring triggered release.