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Related Experiment Videos

Is the pattern of solid-phase gastric emptying different between genders?

M Sanaka1, T Yamamoto, H Anjiki

  • 1Department of Internal Medicine, School of Medicin, Teikyo University, Tokyo, Japan. kuyama@med.teikyo-u.ac.jp

European Journal of Clinical Investigation
|August 9, 2006
PubMed
Summary

Women show a distinct 13CO2 excretion curve pattern, indicating gender-specific gastric emptying (GE). This 13C-octanoate breath test reveals differences in GE patterns between men and women.

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Area of Science:

  • Gastroenterology
  • Physiology
  • Medical Diagnostics

Background:

  • The 13C-octanoate breath test assesses gastric emptying (GE) patterns.
  • Previous studies indicate delayed solid GE in women compared to men.
  • Gender-specific differences in GE patterns are hypothesized.

Purpose of the Study:

  • To investigate if the shape of the 13CO2 excretion curve differs between genders.
  • To compare the GE patterns derived from the 13C-octanoate breath test in men and women.

Main Methods:

  • A dual function y(t) = (a1.tb1 + a2.tb2)e(-K.t) was used to model the 13CO2 excretion curve.
  • Breath samples were collected for 4 hours after consuming a 13C-octanoate labeled muffin.
  • 31 healthy adults (15 men, 16 women) participated in the study.

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Main Results:

  • Both genders displayed a biphasic ascending gradient in the 13CO2 excretion curve.
  • Women exhibited a steeper initial rise and a more blunted subsequent increase compared to men.
  • The descending gradient showed a monotonous decay in both groups.

Conclusions:

  • Women demonstrate a gender-specific 13CO2 excretion profile.
  • This suggests a distinct gastric emptying pattern in women.
  • Potentially stronger post-gastric feedback regulation in women may explain the observed differences.