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Diffusion tensor imaging in schizophrenia.

Monte S Buchsbaum1, Joseph Friedman, Bradley R Buchsbaum

  • 1Neuroscience Positron Emission Tomography Laboratory, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA. monte.buchsbaum@mssm.edu

Biological Psychiatry
|August 9, 2006
PubMed
Summary
This summary is machine-generated.

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Schizophrenia patients exhibit widespread white matter changes, particularly reduced diffusion tensor anisotropy in frontal and callosal regions. These findings highlight significant structural alterations in the brain

Area of Science:

  • Neuroimaging
  • Neurology
  • Psychiatry

Background:

  • Diffusion tensor imaging (DTI) reveals white matter alterations in schizophrenia.
  • Previous studies suggest changes in frontal and frontotemporal white matter.

Purpose of the Study:

  • To investigate white matter structural differences in patients with schizophrenia compared to healthy controls.
  • To identify specific regions affected by altered diffusion tensor anisotropy.

Main Methods:

  • Acquired diffusion tensor anisotropy and anatomical MRI scans from 64 schizophrenia patients and 55 healthy volunteers.
  • Used magnetization prepared rapid gradient echo and pulsed gradient spin-echo sequences for image acquisition.
  • Aligned and warped images to a standard brain space for statistical comparison using significance probability mapping.

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Main Results:

  • Patients with schizophrenia demonstrated widespread areas of reduced diffusion tensor anisotropy.
  • Significant reductions were observed in the frontal white matter, corpus callosum, and frontal longitudinal fasciculus.
  • Findings confirm and extend previous reports of frontal white matter decreases.

Conclusions:

  • The study confirms prominent frontal and callosal white matter alterations in schizophrenia.
  • Reduced anisotropy is widespread in frontal white matter regions of patients.
  • These structural changes provide further evidence for neurobiological differences in schizophrenia.