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Related Experiment Videos

Microencapsulation of drugs by electro-hydro-dynamic atomization.

Tomasz Ciach1

  • 1Warsaw University of Technology, Faculty of Chemical and Process Engineering, Warynskiego St 1, 00-645 Warsaw, Poland. ciach@ichip.pw.edu.pl

International Journal of Pharmaceutics
|August 9, 2006
PubMed
Summary

Electro-hydro-dynamic atomization (EHDA) produces drug-loaded polymeric particles. Hollow particles formed using fast-evaporating solvents show higher drug release rates, with polyethylene glycol further enhancing this effect.

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Area of Science:

  • Materials Science
  • Pharmaceutical Technology
  • Chemical Engineering

Background:

  • Polymeric particles are crucial for controlled drug delivery.
  • Electro-hydro-dynamic atomization (EHDA) offers a method for particle fabrication.
  • Optimizing particle morphology is key to controlling drug release kinetics.

Purpose of the Study:

  • To investigate the practical aspects of producing drug-loaded polymeric particles using EHDA.
  • To analyze the impact of solvent properties and polymer additives on particle characteristics.
  • To correlate particle morphology with drug release rates.

Main Methods:

  • Fabrication of polymeric particles containing paracetamol, budesonide, and paclitaxel using EHDA.
  • Systematic variation of solvent type and evaporation rate.

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  • Inclusion of polymer additives like polyethylene glycol.
  • Morphological characterization of the produced particles.
  • In-vitro assessment of drug release profiles.

    • Main Results:

    • EHDA successfully produced drug-loaded polymeric particles.
    • Solvents with high evaporation rates led to the formation of hollow particles.
    • Hollow particles exhibited significantly higher drug release rates compared to solid particles.
    • Addition of polyethylene glycol increased the drug release rate from the particles.

    Conclusions:

    • Solvent evaporation rate is a critical parameter in controlling particle morphology during EHDA.
    • Hollow particle formation via EHDA can enhance drug release.
    • Polymer additives can be utilized to modulate drug release kinetics from EHDA-produced particles.