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Related Experiment Videos

Fetal cardiac repolarization abnormalities.

Hui Zhao1, Janette F Strasburger, Bettina F Cuneo

  • 1Department of Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, USA.

The American Journal of Cardiology
|August 9, 2006
PubMed
Summary
This summary is machine-generated.

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Fetal long QT syndrome.

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Abnormal fetal T-waves, including QT interval prolongation and T-wave alternans, can now be detected using magnetocardiography in fetuses with cardiac arrhythmia, indicating potential risks. These findings highlight the importance of fetal T-wave assessment for predicting adverse outcomes.

Area of Science:

  • Cardiology
  • Fetal Medicine
  • Biomedical Engineering

Background:

  • Abnormal cardiac repolarization increases sudden cardiac death risk.
  • Little is known about in utero T-wave abnormalities and their link to fetal arrhythmias.
  • Fetal T-wave characteristics are crucial for understanding cardiac health during gestation.

Purpose of the Study:

  • To define fetal T-wave characteristics, including the QT interval, in normal fetuses.
  • To characterize T-wave abnormalities in fetuses diagnosed with cardiac arrhythmia.
  • To assess the diagnostic and prognostic value of fetal T-wave assessment.

Main Methods:

  • Magnetocardiography (MCG) was used to record fetal cardiac electrical activity.
  • Recordings were obtained from 120 fetuses between 14 and 39 weeks' gestation.

Related Experiment Videos

  • QT interval and T-wave alternans were analyzed in fetuses with and without arrhythmia.

    • Main Results:

    • Bazett's formula accurately described the corrected QT interval in normal sinus rhythm fetuses.
    • Fetal arrhythmia showed systematic QT interval deviations at heart rate extremes (QT α RR^0.8).
    • T-wave alternans detected in 7 fetuses with arrhythmia correlated with QT prolongation and adverse outcomes.

    Conclusions:

    • QT interval abnormalities and T-wave alternans are detectable in fetuses with cardiac arrhythmia.
    • These T-wave abnormalities are associated with suboptimal fetal outcomes and fetal demise.
    • T-wave assessment in fetuses with arrhythmia is important for risk stratification and management.