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"Isolated" diastolic dysfunction in left ventricular outflow tract obstruction
Yat-Yin Lam1, Mehmet G Kaya, Omer Goktekin
1Adult Congenital Heart Unit, Royal Brompton Hospital, London, United Kingdom. homalam@hotmail.com
The American Journal of Cardiology
|August 9, 2006
Summary
Isolated diastolic dysfunction is unlikely in young patients with left outflow tract obstruction. Most patients showed reduced systolic velocities, even with normal ejection fractions, challenging the concept of isolated diastolic disease.
Area of Science:
- Cardiology
- Echocardiography
- Diastolic Function
Background:
- Left outflow tract obstruction can affect cardiac function.
- Diastolic dysfunction is a key concern in cardiovascular disease.
Purpose of the Study:
- To investigate the presence of "isolated" diastolic disease in young patients with left outflow tract obstruction.
- To assess long-axis velocities (systolic and diastolic) in this patient cohort.
Main Methods:
- Echocardiographic assessment of 21 young patients with left outflow tract obstruction.
- Analysis of long-axis early diastolic and systolic velocities.
- Evaluation of ejection fraction.
Main Results:
- Most patients exhibited depressed systolic velocities.
- Ejection fractions were generally normal.
- A close relationship was observed between long-axis systolic and diastolic velocities.
Conclusions:
- The findings suggest that "isolated" diastolic disease is unlikely in this population.
- Left outflow tract obstruction appears to impact both systolic and diastolic function concurrently.
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