Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automated method to measure trabecular thickness from microcomputed tomographic scans and its application.

Daniel J McColl1, Richard L Abel, Iain R Spears

  • 1Palaeoanthropology Research Group, Centre for Research in Evolutionary Anthropology, Roehampton University, Holybourne Avenue, London, United Kingdom.

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
|August 9, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chronic developmental exposure to traffic-derived PM<sub>2.5</sub> has limited skeletal effects in mice.

Scientific reports·2026
Same author

How muscle talks to brain: apelin protein mediates exercise-induced antidepressant effects.

Molecular psychiatry·2026
Same author

Runaway resorption of microcracks contributes to age-related hip-fracture patients.

Scientific reports·2025
Same author

Climate and Human Evolution: Insights from Marine Records.

Annual review of marine science·2024
Same author

A Cross-Sectional Study of Bone Nanomechanics in Hip Fracture and Aging.

Life (Basel, Switzerland)·2023
Same author

Association between nanoscale strains and tissue level nanoindentation properties in age-related hip-fractures.

Journal of the mechanical behavior of biomedical materials·2022

This study introduces a novel computer application to accurately measure trabecular thickness in bone using nondestructive imaging. The method shows good agreement with traditional techniques, improving bone integrity analysis.

Area of Science:

  • Biomedical Engineering
  • Orthopedic Research
  • Bone Histology

Background:

  • Trabeculae are crucial for bone strength and integrity, with thickness being a key measure.
  • Assessing trabecular thickness is vital for understanding bone development, aging, and mineral homeostasis.
  • Nondestructive imaging techniques like micro-computed tomography (muCT) and magnetic resonance imaging (MRI) face challenges in accurately quantifying trabecular thickness due to technical limitations.

Purpose of the Study:

  • To present a novel computer application designed to overcome limitations in measuring trabecular thickness using nondestructive imaging techniques.
  • To validate the accuracy of the new method against established techniques and histological data.
  • To investigate ontogenetic trends in trabecular thickness in human fetal ilia.

Related Experiment Videos

Main Methods:

  • Development of a computer application for trabecular thickness quantification.
  • Validation using a physical phantom and comparison with histological sections of bone.
  • Application of the method to modern human fetal ilia samples.

Main Results:

  • The computer application demonstrated good agreement with measurements from both phantom models and histological sections.
  • Analysis of human fetal ilia revealed a trend of increasing trabecular thickness during ontogeny, consistent with existing histological data.
  • Discrepancies were noted, potentially due to partial volume effects and inherent limitations of histological sectioning, such as shrinkage and distortion.

Conclusions:

  • The developed computer application offers a reliable method for measuring trabecular thickness non-destructively.
  • This tool aids in overcoming challenges associated with traditional imaging and histological analysis of bone microarchitecture.
  • Accurate trabecular thickness measurement is essential for advancing research in bone biology, development, and disease.