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Updated: Aug 6, 2026
In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
[Effect of compound glycyrrhizin on peripheral T-lymphocyte subset in AIDS patients]
Wen-hu Yao1, Wei Zhao, Yin-wei Wu
1Department of Infections, the Second Hospital of Nanjing Affiliated to Southeast University Medical College, Nanjing, Jiangsu 210003, China. ywh1950@sina.com
Objective:
To probe the effect and mechanism of Compound Glycyrrhizin in treating AIDS.
Methods:
Forty AIDS patients were randomly divided into a treatment group and a control group, both treated with HAART. In addition, the former was given Compound Glycyrrhizin for 6 months, and the CD4+ T count and the expressions of CD8+ and HLA-DR on the surface of peripheral blood lymphocytes (PBL) were studied before and after the treatment.
Results:
After 6 months of treatment, the expressions of CD8+ and CD38+ of PBL in the treatment group [(6.6 +/- 2.1)%] were found lower than in the control [(11.4 +/- 3.8)%] (t = 5.043, P < 0.01) and CD4+ T count [(243.6 +/- 91.2) x 10(6)/L vs (170.8 +/- 55.7) x 10(6)/L] rose more significantly (t = 3.045, P < 0.01).
Conclusion:
Compound Glycyrrhizin can lower the expression of active T-lymphocyte subset, inhibit HIV and help immune reconstitution.
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