Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

TREAD: TReatment with Exercise Augmentation for Depression: study rationale and design.

Madhukar H Trivedi1, Tracy L Greer, Bruce D Grannemann

  • 1Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. madhukar.trivedi@utsouthwestern.edu

Clinical Trials (London, England)
|August 10, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric nurse perspectives on patient- and family-centered rounds: A qualitative study.

Journal of hospital medicine·2025
Same author

Neural substrates of emotional conflict with anxiety in major depressive disorder: Findings from the Establishing Moderators and biosignatures of Antidepressant Response in Clinical Care (EMBARC) randomized controlled trial.

Journal of psychiatric research·2022
Same author

Psychometric properties of the Generalized Anxiety Disorder 7-item scale in youth: Screening in a primary care sample.

Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists·2021
Same author

The Youth Aware of Mental Health Intervention: Impact on Help Seeking, Mental Health Knowledge, and Stigma in U.S. Adolescents.

The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2020
Same author

Reduced anti-inflammatory gut microbiota are associated with depression and anhedonia.

Journal of affective disorders·2020
Same author

An electroencephalographic signature predicts antidepressant response in major depression.

Nature biotechnology·2020

Exercise may effectively augment antidepressant treatment for major depressive disorder (MDD). The TREAD study investigates aerobic exercise as an add-on therapy for patients with persistent MDD symptoms, aiming to improve treatment outcomes.

Area of Science:

  • Clinical Psychology
  • Psychiatry
  • Exercise Physiology

Background:

  • Many patients with major depressive disorder (MDD) do not achieve full symptom remission with standard antidepressant medication.
  • Exercise shows promise in reducing depressive symptoms, but its role as an augmentation strategy in controlled trials for MDD is underexplored.

Purpose of the Study:

  • The Treatment with Exercise Augmentation for Depression (TREAD) study is a randomized controlled trial.
  • It assesses the efficacy of two aerobic exercise dosages as an augmentation strategy for selective serotonin reuptake inhibitor (SSRI) treatment in MDD patients.

Main Methods:

  • The TREAD study involves 12 weeks of treatment followed by a 12-week follow-up period.
  • Primary outcome is the change in depressive symptoms, with secondary assessments of psychosocial function and treatment adherence.

Related Experiment Videos

  • The design addresses challenges in patient-oriented research, including augmentation strategies, non-pharmacological interventions, and adherence programs.

    • Main Results:

    • This paper details the rationale and design of the TREAD study.
    • It highlights the integration of augmentation strategies, non-pharmacological treatments, and robust trial design.
    • Implementation of an exercise adherence program is also discussed.

    Conclusions:

    • The TREAD study is designed to minimize bias and enhance validity in research on exercise for mental health.
    • A multidisciplinary team with expertise in depression and exercise physiology facilitates the study.
    • This rigorous approach aims to provide reliable evidence on exercise as an MDD augmentation strategy.