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[Poisoning with cholinesterase inhibitors]
1Dipartimento di medicina interna e centro di cure intense, Ospedale San Giovanni, Bellinzona.
Schweizerische Medizinische Wochenschrift
|February 10, 1990
Summary
A woman survived a fatal dose of Fonofos insecticide after prompt medical intervention. Treatment included mechanical ventilation, gastric lavage, atropine, and obidoxime, leading to full recovery.
Area of Science:
- Toxicology
- Emergency Medicine
- Pharmacology
Background:
- Cholinesterase inhibitor insecticides pose significant poisoning risks.
- Fonofos is a potent organophosphate insecticide with high toxicity.
Observation:
- A 32-year-old female ingested a large quantity (300 ml) of Fonofos with suicidal intent.
- The patient rapidly progressed to coma and respiratory arrest.
Findings:
- Aggressive medical management, including tracheal intubation, mechanical ventilation, gastric lavage, atropine, and obidoxime, was initiated.
- Complete clinical recovery was achieved within 24 hours of Fonofos ingestion.
Implications:
- Early and intensive medical intervention can be life-saving in severe organophosphate poisoning.
- Atropine and obidoxime are critical in managing cholinesterase inhibitor toxicity.
- This case highlights the potential for recovery even after massive exposure to potent insecticides.