Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone mineral density-affecting genes in Africans.

Gordon Gong1, Gleb Haynatzki, Vera Haynatzka

  • 1Center, University of Texas at Houston, Houston, TX, USA. gordon.gong@ttuhsc.edu

Journal of the National Medical Association
|August 10, 2006
PubMed
Summary

Genetic variations in bone mineral density (BMD) genes differ significantly between Sudanese populations and other ethnic groups. These genetic differences may contribute to ethnic diversity in BMD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Fast Component of Visual Field Decay Rate Correlates With Disc Rim Area Change Throughout the Entire Range of Glaucomatous Damage.

Investigative ophthalmology & visual science·2015
Same author

International Outcomes of the Boston Type I Keratoprosthesis in Stevens-Johnson Syndrome.

Cornea·2015
Same author

Insights triggered by textual micro-counseling dialogues of restructuring orientation in experts and students.

PsyCh journal·2015
Same author

Water-enhanced Removal of Ciprofloxacin from Water by Porous Graphene Hydrogel.

Scientific reports·2015
Same author

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41.

Current topics in medicinal chemistry·2015
Same author

Synthesis and biological evaluation of ring A and/or C expansion and opening echinocystic acid derivatives for anti-HCV entry inhibitors.

European journal of medicinal chemistry·2015

Area of Science:

  • Human genetics
  • Bone biology
  • Population genetics

Background:

  • Ethnic diversity in bone mineral density (BMD) is influenced by environmental factors.
  • The role of genetic differences in ethnic BMD variations requires further investigation.

Purpose of the Study:

  • To determine allele frequencies of BMD-associated genes in an African population.
  • To investigate the association between these gene variants and BMD in Africans.

Main Methods:

  • Analysis of allele frequencies at 18 polymorphic sites in 13 BMD-related genes.
  • Study conducted on 143 recent immigrants from Sudan to the United States.
  • Genetic association studies performed on single-nucleotide polymorphisms (SNPs) and microsatellite alleles.

Related Experiment Videos

Main Results:

  • Significant differences in allele frequencies were observed between Sudanese and Asian/Caucasian populations for 10 out of 14 SNPs.
  • Allele frequencies for TGFB, COL1A1, and CSR genes were notably low (<0.04) in the Sudanese group.
  • SNPs in VDR and ERalpha genes showed associations with BMD and bone mineral content (BMC) at various skeletal sites.

Conclusions:

  • Genetic variations likely contribute to the observed ethnic diversity in BMD and BMC.
  • Further research into specific gene-environment interactions is warranted.