Search research articles

Search research articles

Related Experiment Videos

Understanding stress through the genome.

¹Division of Medical Pharmacology, Leiden/Amsterdam Center for Drug Research and Leiden University Medical Center, PO Box 9503, Leiden, 2300 RA, The Netherlands. o.meijer@lacdr.leidenuniv.nl

Stress (Amsterdam, Netherlands)

|August 10, 2006

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Functional polygenic risk score of glucocorticoid-dependent regulatory element activity and its relation to clinical and stress-related phenotypes.

Psychoneuroendocrinology·2025

Same author

The multi-faceted nature of age-associated osteoporosis.

Bone reports·2024

Same author

An integrated single-cell RNA-seq atlas of the mouse hypothalamic paraventricular nucleus links transcriptomic and functional types.

Journal of neuroendocrinology·2024

Same author

Glucocorticoid Receptor (GR) antagonism as disease-modifying treatment for MDD with childhood trauma: protocol of the RESET-medication randomized controlled trial.

BMC psychiatry·2023

Same author

Exploring the choroidal vascular labyrinth and its molecular and structural roles in health and disease.

Progress in retinal and eye research·2021

Same author

Potential associations between immune signaling genes, deactivated microglia, and oligodendrocytes and cortical gray matter loss in patients with long-term remitted Cushing's disease.

Psychoneuroendocrinology·2021

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Glucocorticoid hormones help organisms adapt to stress by regulating gene expression. Understanding distinct gene classes and their regulation mechanisms enhances our knowledge of stress adaptation.

Area of Science:

Endocrinology
Molecular Biology
Genetics

Background:

Glucocorticoid hormones are crucial for stress adaptation and coping mechanisms.
These hormones modulate gene expression via corticosteroid receptors acting as transcription factors.
Regulation is tissue and stressor-specific.

Purpose of the Study:

To discuss recent insights into glucocorticoid-mediated gene regulation.
To categorize target genes based on transcription factor binding sites and regulatory mechanisms.
To enhance understanding of organismal stress response through mechanistic insights.

Main Methods:

Categorization of target genes based on transcription factor binding site combinations.
Analysis of distinct transcriptional regulation mechanisms (transactivation vs. transrepression).

Related Experiment Videos

Consideration of hormone receptor binding affinity (high vs. low).

Main Results:

Distinct classes of glucocorticoid target genes can be defined.
These classes are based on specific transcription factor binding site configurations.
Mechanistic understanding of regulation (e.g., transactivation/transrepression) is key.

Conclusions:

Classifying genes based on regulatory mechanisms and binding sites refines understanding of glucocorticoid action.
Integrating this with genomic and expression data offers deeper insights into stress adaptation.
This approach advances our comprehension of how organisms manage diverse stressors.