Iontophoretic transdermal delivery of haloperidol
M J Alvarez-Figueroa1, I Araya-Silva, C Díaz-Tobar
1Departamento de Farmacia, Facultad de Química, Pontificia Universidad Católica de Chile, Santiago de Chile, Chile. mjalvare@uc.cl
Pharmaceutical Development and Technology
|August 10, 2006
Summary
Anodal iontophoresis significantly enhanced haloperidol (HP) skin delivery and accumulation compared to passive methods. This study shows iontophoresis can improve topical HP application for chronic psychosis treatment.
Area of Science:
- Pharmacology
- Drug Delivery
- Dermatology
Background:
- Topical drug delivery faces challenges in achieving adequate therapeutic concentrations.
- Haloperidol (HP) is a key antipsychotic medication.
- Improving transdermal delivery of HP could enhance treatment efficacy and patient compliance.
Purpose of the Study:
- To investigate the in vitro iontophoretic transdermal delivery of haloperidol (HP) across pig skin.
- To evaluate the impact of various parameters on HP iontophoretic transport.
Main Methods:
- In vitro iontophoresis across excised pig skin.
- Anodal iontophoresis was compared to passive diffusion controls.
- Variations in NaCl concentration, HP concentration, and current density were assessed.
Main Results:
- Anodal iontophoresis significantly increased HP skin penetration and accumulation versus passive controls.
- Increased NaCl concentration reduced HP iontophoretic transport.
- HP concentration (0.4-0.9 mg/mL) did not significantly alter electrotransport, except at 24 hours.
- HP iontophoretic transport generally increased with current density (0.20-0.50 mA/cm2).
Conclusions:
- Iontophoresis is a viable method to enhance the transdermal delivery of haloperidol.
- Optimizing parameters like current density and vehicle composition can improve HP delivery.
- This technique holds promise for improving topical applications of HP in managing chronic psychosis.
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