Related Experiment Videos

MDM2 SNP309 and SNP354 are not associated with lung cancer risk

Sharon R Pine1, Leah E Mechanic, Elise D Bowman

  • 1Laboratory of Human Carcinogenesis, National Cancer Institute, Room 3068, Building 37, 37 Convent Drive, Bethesda, MD 20892-4258, USA.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
|August 10, 2006
PubMed

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Single Nucleotide Polymorphisms-SNPs

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Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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