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Species-specific Mn2+/Mg2+ antiport from Mg2(+)-loaded erythrocytes
T Günther1, J Vormann, E J Cragoe
1Institute of Molecular Biology and Biochemistry, Free University of Berlin, FRG.
FEBS Letters
|February 22, 1990
Abstract:
Mg2(+)-loaded rat erythrocytes performed Mn2+/Mg2+ antiport, which was nonspecifically stimulated by anions and cations. Mn2+/Mg2+ antiport was shown to operate via the Na+/Mg2+ antiporter because extracellular Na+ and Mn2+ inhibited the intracellular uptake of each other's ions competitively. Furthermore, Mn2+/Mg2+ antiport and Na+/Mg2+ antiport were identically inhibited by various amiloride derivatives. Na+/Mg2+ antiport of chicken and human erythrocytes cannot perform Mn2+/Mg2+ antiport although chicken erythrocytes took up more Mn2+ than rat erythrocytes.