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Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice
Published on: October 3, 2010
Anaplastic medulloblastoma with granular cell change
Fausto J Rodriguez1, Bernd W Scheithauer
1Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, SW, Rochester, MN 55905, USA.
Acta Neuropathologica
|August 10, 2006
Summary
Granular cell change, typically seen in glial or schwannian tumors, was observed in an anaplastic medulloblastoma. This finding expands the known spectrum of granular cell change to include neuronal tumors.
Area of Science:
- Neuro-oncology
- Cellular pathology
- Tumor biology
Background:
- Granular cell change is a histological feature observed in nervous system tumors.
- It is often associated with lysosomal accumulation.
- Previously, this change was primarily linked to glial or schwannian tumors.
Observation:
- A case of anaplastic medulloblastoma in a 15-year-old female is presented.
- Histological examination revealed areas exhibiting granular cell change.
- Ultrastructural analysis showed lysosomal accumulation and dense core granules within these cells.
Findings:
- The granular cells within the anaplastic medulloblastoma co-expressed neuronal markers (synaptophysin, chromogranin, Neu-N).
- This indicates a neuronal origin for these granular cells.
- The findings demonstrate granular cell change in a tumor of primarily neuronal differentiation.
Implications:
- The study suggests expanding the definition of granular cell change to encompass neuronal tumors.
- This finding may impact the differential diagnosis of central nervous system tumors.
- Further research is warranted to understand the mechanisms driving granular cell change in neuronal neoplasms.
