Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immunology in schizophrenic disorders].

N Müller1, M J Schwarz

  • 1Klinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität, Nussbaumstrasse 7, 80336 München. Norbert.Mueller@med.uni-muenchen.de

Der Nervenarzt
|August 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Markers of the innate immune system in the cerebrospinal fluid in patients with severe depression.

Acta psychiatrica Scandinavica·2017
Same author

Elevated macrophage migration inhibitory factor and decreased transforming growth factor-beta levels in major depression--no influence of celecoxib treatment.

Journal of affective disorders·2011
Same author

Reversal of imbalance between kynurenic acid and 3-hydroxykynurenine by antipsychotics in medication-naïve and medication-free schizophrenic patients.

Brain, behavior, and immunity·2011
Same author

Elevated S100B levels in schizophrenia are associated with insulin resistance.

Molecular psychiatry·2009
Same author

Effects of experimentally induced panic attacks on neuroimmunological markers.

Journal of neural transmission (Vienna, Austria : 1996)·2008
Same author

A European consensus for the evaluation and management of infants with an equivocal diagnosis following newborn screening for cystic fibrosis.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2008
Same journal

[When brain abscesses run in the family…].

Der Nervenarzt·2026
Same journal

[Digital health applications and adherence in depression: a qualitative study from the perspective of healthcare providers].

Der Nervenarzt·2026
Same journal

Der Nervenarzt·2026
Same journal

[Rare genetic diseases with frequent mental symptoms].

Der Nervenarzt·2026
Same journal

Der Nervenarzt·2026
Same journal

Der Nervenarzt·2026
See all related articles

Inflammation and immune responses may drive schizophrenia by increasing kynurenine acid. This molecule disrupts N-methyl-D-aspartate (NMDA) receptors, impacting cognition and causing psychosis.

Area of Science:

  • Psychoneuroimmunology
  • Neurobiology
  • Neurochemistry

Context:

  • Schizophrenia pathogenesis is complex, involving neurochemical and genetic factors.
  • Dopaminergic neurotransmission is central, modulated by the glutamatergic system.
  • N-methyl-D-aspartate (NMDA) receptor hypofunction is implicated in schizophrenia.

Purpose:

  • To present a model integrating psychoneuroimmunologic findings with neurobiological and genetic data in schizophrenia.
  • To elucidate the role of immune-mediated inflammation in schizophrenia pathogenesis.
  • To explain how kynurenine acid accumulation may cause psychotic and cognitive symptoms.

Summary:

  • A model proposes that prenatal infections sensitize the immune system, leading to an imbalance that inhibits indoleamine 2,3-dioxygenase (IDO).

Related Experiment Videos

  • This inhibition shifts tryptophan metabolism towards kynurenine production via tryptophan 2,3-dioxygenase (TDO) in astrocytes.
  • Accumulated kynurenine acid acts as an endogenous N-methyl-D-aspartate (NMDA) receptor antagonist, causing glutamatergic-dopaminergic dysregulation and schizophrenia symptoms.

    • Impact:

    • Provides a unifying framework for understanding schizophrenia's neurobiology and immune underpinnings.
    • Suggests novel therapeutic targets, such as modulating inflammatory pathways or kynurenine metabolism.
    • Highlights the link between immune system dysregulation and neurochemical imbalances in psychiatric disorders.