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Updated: Aug 6, 2026
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Published on: August 9, 2024
Adenoid cystic carcinoma arising from the lower eyelid
Hiroshi Goto1, Tatsuro Yamamoto2, Zenzo Ishiyama2
1Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan. goto1115@tokyo-med.ac.jp.
Background:
Primary cutaneous adenoid cystic carcinoma is one of the rarest eyelid tumors.
Case:
A 39-year-old man presented with a small subcutaneous induration in his left lower eyelid close to the lower lacrimal punctum.
Observations:
Under a clinical diagnosis of chalazion, the eyelid induration was extracted surgically via the palpebral conjunctiva. Histopathological examination of the extracted tumor revealed proliferation of basaloid cells with a prominent cribriform pattern containing Alcian blue-positive and periodic acid Schiff-positive material, leading to a diagnosis of adenoid cystic carcinoma. The patient subsequently underwent extended radical excision including the lacrimal sac. No recurrence was observed during 20 months after surgery.
Conclusions:
Adenoid cystic carcinoma should be considered as a differential diagnosis of eyelid tumors simulating chalazion. Adenoid cystic carcinoma in the eyelid may have a more favorable prognosis than that in the lacrimal gland.
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