Related Experiment Video
Updated: Aug 6, 2026

An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
Published on: March 30, 2014
Drug use and medication adherence among HIV-1 infected individuals
Charles H Hinkin1, Terry R Barclay, Steven A Castellon
1David Geffen School of Medicine, University of California at Los Angeles, 760 Westwood Plaza, Room C8-747, Los Angeles, CA 90024, USA. chinkin@ucla.edu
Abstract:
This longitudinal study examined the impact of drug use and abuse on medication adherence among 150 HIV-infected individuals, 102 who tested urinalysis positive for recent illicit drug use. Medication adherence was tracked over a 6-month period using an electronic monitoring device (MEMS caps). Over the 6-month study drug-positive participants demonstrated significantly worse medication adherence than did drug-negative participants (63 vs. 79%, respectively). Logistic regression revealed that drug use was associated with over a fourfold greater risk of adherence failure. Stimulant users were at greatest risk for poor adherence. Based upon within-participants analyses comparing 3-day adherence rates when actively using versus not using drugs, this appears to be more a function of state rather than trait. These data suggest that it is the acute effects of intoxication, rather than stable features that may be characteristic of the drug-using populace, which leads to difficulties with medication adherence.
Related Concept Videos
Drug Therapy
Antianxiety Medications
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Retrovirus Life Cycles
Therapeutic Drug Monitoring: Affecting Factors
Drug Dependence
Pharmacokinetics in Pediatric Patients: Drug Excretion

