Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in contralateral protein metabolism following unilateral sciatic nerve section.

J A Menéndez1, S C Cubas

  • 1División Biofísica, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay.

Journal of Neurobiology
|March 1, 1990
PubMed
Summary

Nerve injury triggers contralateral changes in protein metabolism. Electrical signals, not axoplasmic flow, transmit these effects, as shown by amino acid incorporation studies in sciatic nerves.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A theory of brain-computer interface learning via low-dimensional control.

bioRxiv : the preprint server for biology·2024
Same author

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism.

Oncogene·2017
Same author

Fatty acid synthase regulates estrogen receptor-α signaling in breast cancer cells.

Oncogenesis·2017
Same author

Microwave-induced cracking of pyrolytic tars coupled to microwave pyrolysis for syngas production.

Bioresource technology·2016
Same author

Mapping of the circulating metabolome reveals α-ketoglutarate as a predictor of morbid obesity-associated non-alcoholic fatty liver disease.

International journal of obesity (2005)·2014
Same author

Microwave pyrolysis of microalgae for high syngas production.

Bioresource technology·2013

Area of Science:

  • Neuroscience
  • Cellular Biology
  • Biochemistry

Background:

  • Contralateral nerve changes after injury are documented but poorly understood.
  • Potential mechanisms include axoplasmic flow or electrical signaling.

Purpose of the Study:

  • To investigate the mechanism behind contralateral changes in protein metabolism after nerve injury.
  • To differentiate between axoplasmic transport and electrical signaling pathways.

Main Methods:

  • Unilateral sciatic nerve section in rats.
  • Assessment of labeled amino acid incorporation into proteins via liquid scintillation.
  • Application of lidocaine or colchicine to investigate signal transmission.

Main Results:

Related Experiment Videos

  • Increased amino acid incorporation observed in both injured and contralateral nerves 14-24 hours post-injury.
  • Lidocaine application inhibited the contralateral effect, while colchicine did not.
  • No significant difference in incorporation between sectioned and intact nerves.

    • Conclusions:

    • Electrical signals transmitted via the spinal cord are responsible for contralateral nerve changes.
    • The precise proteins affected and the functional significance of these contralateral changes remain speculative.