Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Do carbamates cause polyneuropathy?

Marcello Lotti1, Angelo Moretto

  • 1Department of Environmental Medicine and Public Health, University of Padua, Padua, Italy.

Muscle & Nerve
|August 10, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction of Williams et al. (2000) does not affect the conclusions of the 2016 FAO/WHO JMPR evaluation of glyphosate.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Risk of SARS-CoV-2 Reinfections Among Healthcare Workers of Four Large University Hospitals in Northern Italy: Results of an Online Survey Within the ORCHESTRA Project.

Vaccines·2025
Same author

Evaluating the consistency of judgments derived through both in silico and expert application of the Cramer classification scheme.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2024
Same author

Revealing the Hidden Impacts: Insights into Biological Aging and Long-Term Effects in Pauci- and Asymptomatic COVID-19 Healthcare Workers.

International journal of molecular sciences·2024
Same author

Long term follow-up of heart rate variability in healthcare workers with mild COVID-19.

Frontiers in neurology·2024
Same author

Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge-ORCHESTRA project.

Infection·2024
Same journal

Join AANEM.

Muscle & nerve·2026
Same journal

Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

Muscle & nerve·2026
Same journal

AANEM News & Insights.

Muscle & nerve·2026
Same journal

Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

Muscle & nerve·2026
Same journal

Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

Muscle & nerve·2026
Same journal

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

Muscle & nerve·2026
See all related articles

Carbamate pesticides may cause polyneuropathy, challenging previous assumptions. Individuals with underlying neuropathy exposed to carbamates require close monitoring and risk assessments may need revision.

Area of Science:

  • Neurotoxicology
  • Environmental Health

Background:

  • Carbamates are known reversible acetylcholinesterase inhibitors.
  • Some carbamates also inhibit neuropathy target esterase (NTE), implicated in organophosphate-induced delayed polyneuropathy.
  • Mechanistic theories suggested carbamates could not initiate polyneuropathy, leading to dismissal of related clinical reports.

Observation:

  • Three cases of polyneuropathy following severe methylcarbamate poisoning are presented.
  • Experimental administration of phenyl N-methyl N-benzylcarbamate induced significant NTE inhibition and polyneuropathy in a hen model.
  • These findings challenge the established understanding of carbamate neurotoxicity.

Findings:

  • Carbamate exposure can lead to polyneuropathy, contrary to prior beliefs.

Related Experiment Videos

  • High doses of specific carbamates can cause substantial NTE inhibition and induce neuropathic symptoms.
  • The study questions whether carbamates initiate or merely exacerbate pre-existing neuropathies.

    • Implications:

    • Clinical reports of carbamate-induced polyneuropathy warrant reconsideration.
    • Individuals with subclinical neuropathies (e.g., diabetes) may be at increased risk.
    • Current risk assessment protocols for carbamate pesticides may require re-evaluation to include polyneuropathy potential.