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Updated: Aug 6, 2026

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Optically active trans-2-aminocyclopentanols: chemoenzymatic preparation and application as chiral ligands
Javier González-Sabín1, Vicente Gotor, Francisca Rebolledo
1Departamento de Química Orgánica e Inorgánica e Instituto de Biotecnología, Universidad de Oviedo, Oviedo, Spain.
Abstract:
Optically active trans-2-(N,N-dialkylamino)cyclopentanols and their acetates derivatives were obtained with very good chemical yields and enantiomeric excesses (95->/=99%), through a chemoenzymatic methodology based on the lipase-catalyzed acylation of the hydroxyl group. The utility of these compounds was shown by the preparation of the cyclopentylic analog of vesamicol and by their use as ligands in the enantioselective addition of diethylzinc to benzaldehyde.
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