[Peripheral blood lymphocytes T gammadelta in children with acute acquired toxoplasmosis]
K Kmieć1, T Woźniakowska-Gesicka
1III Klinika Pediatrii ICZMP, 93-338 Lódź, ul. Rzgowska 281/289.
Insights
In children with acute toxoplasmosis, the percentage of CD3TCR gamma delta T-cells increased, suggesting their role in infection diagnosis. This finding aids in identifying acute Toxoplasma gondii infections.
Area of Science:
- Immunology
- Infectious Diseases
- Pediatrics
Context:
- Toxoplasmosis is a significant public health concern, particularly in pediatric populations.
- Understanding the immune response to Toxoplasma gondii infection is crucial for diagnosis and management.
- Gamma delta T-cells (γδ T-cells) are known to play a role in innate immunity and early responses to pathogens.
Purpose:
- To investigate the percentage of CD3TCR γδ T-cells in the peripheral blood of children diagnosed with acute toxoplasmosis.
- To compare these levels with a control group of children without active infection.
- To assess the diagnostic potential of CD3TCR γδ T-cell enumeration in acute toxoplasmosis.
Summary:
- The study analyzed 30 children (aged 2-14 years) with acute toxoplasmosis.
- A higher mean percentage of CD3TCR γδ T-cells was observed in children with clinical toxoplasmosis (5.7%) compared to controls (4.4%).
- Notably, 40% of infected children exhibited elevated levels (mean 8.1%), indicating a strong immune activation signal.
Impact:
- Elevated CD3TCR γδ T-cell percentages correlate with active Toxoplasma gondii infection in children.
- Measuring these cells could serve as a valuable biomarker for diagnosing the acute phase of toxoplasmosis.
- This research contributes to improved diagnostic strategies for pediatric parasitic infections.
Abstract:
The aim of the study was to determine the percentage participation of lymphocytes CD3TCRgammadelta in peripheral blood of children with acute toxoplasmosis. The study compromised 30 children aged 2-14 years. Increase of the percentage of CD3TCR gammadelta cells was observed in the group of children with clinical symptoms of toxoplasmosis (mean value 5.7%) in relation to the comparative group (mean 4.4%), but in 12 children (40%) the mean value was 8.1%. Toxoplasma gondii infection produces a strong signal for activation of cells with gammadelta receptors. Examination of CD3TCRgammadelta cells may be helpful in the diagnosis of the acute phase of T. gondii infection.
