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[S-1 as a single agent for colorectal cancer]
Takako Eguchi1, Kuniaki Shirao
1Dept. of Gastrointestinal Oncology, National Cancer Center Hospital, Tokyo, Japan.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|August 11, 2006
Summary
S-1, an oral chemotherapy drug, shows significant activity and tolerable toxicity in treating metastatic colorectal cancer. This 5-fluorouracil (5-FU) based drug is a promising option for colorectal cancer treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Colorectal cancer chemotherapy is rapidly advancing with new agents.
- 5-fluorouracil (5-FU) remains a cornerstone treatment for colorectal cancer.
Purpose of the Study:
- To evaluate the efficacy and safety of S-1 as a single agent for metastatic colorectal cancer.
Main Methods:
- Phase II clinical study of S-1, an oral 5-FU prodrug.
- S-1 comprises tegafur, 5-chloro-2,4-dihydroxypyridine (inhibits DPD), and potassium oxonate (reduces GI toxicity).
Main Results:
- S-1 demonstrated significant activity as a single agent in metastatic colorectal cancer.
- Complete Response (CR) rates ranged from 36-40% with a Median Survival Time (MST) of approximately one year.
- Observed toxicities were generally tolerable.
Conclusions:
- S-1 is an active and well-tolerated oral chemotherapy agent for metastatic colorectal cancer.
- Ongoing trials are investigating S-1 in combination with oxaliplatin, CPT-11, and molecular targeting drugs.
- S-1 is anticipated to play a crucial role in future colorectal cancer chemotherapy regimens.
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