Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Post infectious irritable bowel syndrome experimental model].

Nobuhide Oshitani1, Hirokazu Yamagami, Kenji Watanabe

  • 1Department of Gastroenterology, Osaka City University Graduate School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 11, 2006
PubMed
Summary

Irritable bowel syndrome (IBS) may stem from early life stress or infection, leading to lasting gut issues. Animal models show these factors cause prolonged intestinal hyper-kinesis and pain, suggesting new IBS treatment targets.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smoking and drinking habits relating to development of ulcerative colitis in Japanese: A multicenter case-control study.

JGH open : an open access journal of gastroenterology and hepatology·2023
Same author

Gastrointestinal endoscopic practice during COVID-19 pandemic: a multi-institutional survey.

Romanian journal of internal medicine = Revue roumaine de medecine interne·2021
Same author

Novel prognostic biomarkers of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: Neutrophil-to-lymphocyte ratio.

PloS one·2020
Same author

Safety of Endoscopic Mucosal Resection Using a Bipolar Snare for Superficial Nonampullary Duodenal Epithelial Tumors and the Predictive Factors of Piecemeal Resection.

Digestion·2020
Same author

Association of Dietary Fatty Acid Intake With the Development of Ulcerative Colitis: A Multicenter Case-Control Study in Japan.

Inflammatory bowel diseases·2020
Same author

Non-adherence to Medications in Pregnant Ulcerative Colitis Patients Contributes to Disease Flares and Adverse Pregnancy Outcomes.

Digestive diseases and sciences·2020

Area of Science:

  • Gastroenterology
  • Immunology
  • Neuroscience

Background:

  • Irritable bowel syndrome (IBS) encompasses functional gastrointestinal disorders, potentially including post-infectious and post-inflammatory subtypes.
  • Neonatal stress or bowel irritation in animal models can lead to adult-onset intestinal hyper-kinesis and visceral hyperalgesia.

Purpose of the Study:

  • To investigate the mechanisms underlying functional gastrointestinal disorders, specifically post-infectious IBS, using experimental models.
  • To explore the role of immune responses and specific cytokines in the development of intestinal dysfunction following infection.

Main Methods:

  • Development and utilization of murine models to simulate neonatal stress and infectious challenges.
  • Assessment of intestinal muscle activity (hyper-kinesis) and visceral pain sensitivity (hyperalgesia) in adult animals.

Related Experiment Videos

  • Analysis of cytokine profiles, including Th2 cytokines and TGF-beta1, in response to nematode infection.

    • Main Results:

    • Neonatal psychological stress or bowel irritation induced prolonged intestinal hyper-kinesis and visceral hyperalgesia in adult mice.
    • A murine infectious experiment successfully reproduced adult post-infectious functional gastrointestinal disorders.
    • Acute phase Th2 cytokine production and sustained TGF-beta1 levels were identified as key contributors to intestinal hyper-kinesis in a post-nematode infectious rat model.

    Conclusions:

    • Experimental models suggest that IBS pathogenesis can be further subdivided based on etiological factors like early-life stress and infection.
    • The findings highlight the involvement of specific immune pathways, such as Th2 and TGF-beta1 signaling, in post-infectious gut dysfunction.
    • These experimental insights are expected to pave the way for novel therapeutic strategies targeting the underlying mechanisms of IBS.