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Related Experiment Videos

[A study on enoxacin concentration in human prostatic tissue].

Y Kitamura1, Z Kataumi, T Nakamura

  • 1Department of Urology, Konodai Hospital National Center of Neurology and Psychiatry.

Hinyokika Kiyo. Acta Urologica Japonica
|January 1, 1990
PubMed
Summary
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Enoxacin effectively penetrates prostatic tissue in patients with benign prostatic hyperplasia. Prostatic tissue levels of enoxacin were higher than serum concentrations after oral administration.

Area of Science:

  • Pharmacology
  • Urology
  • Drug Penetration Studies

Context:

  • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
  • Understanding drug penetration into prostatic tissue is crucial for effective BPH treatment.
  • Enoxacin is a fluoroquinolone antibiotic with potential applications beyond infection treatment.

Purpose:

  • To quantify enoxacin concentration in both serum and prostatic tissue.
  • To assess the penetration of enoxacin into the prostate gland.
  • To evaluate enoxacin's potential for treating BPH-related conditions.

Summary:

  • Enoxacin was administered orally to patients undergoing surgery for BPH.
  • Serum and prostatic tissue concentrations of enoxacin were measured during the operation.

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  • Mean enoxacin concentration was 2.84 µg/ml in serum and 4.60 µg/ml in prostatic tissue.

    • Impact:

    • Demonstrates significant enoxacin penetration into prostatic tissue.
    • Suggests enoxacin may have therapeutic potential in managing BPH.
    • Provides data for further research into enoxacin's efficacy for urological conditions.