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Plasma lipids and blood viscosity in patients with cerebrovascular disease

Irena Velcheva1, Nadia Antonova, Valentina Dimitrova

  • 1Department of Neurology, Medical University, 1, Ljuben Russev str., 1113 Sofia, Bulgaria. ivelcheva@yahoo.com

Clinical Hemorheology and Microcirculation
|August 11, 2006
PubMed

Insights

Elevated plasma triglycerides (Tg) significantly impair blood fluidity and cerebral circulation in patients with cerebrovascular disease (CVD). This study highlights Tg

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Hematology

Background:

  • Plasma lipids are known to elevate cerebrovascular risk by altering hemorheological profiles.
  • Understanding the interplay between lipids and blood flow is crucial for managing cerebrovascular disease (CVD).

Purpose of the Study:

  • To investigate the relationship between blood viscosity parameters and plasma lipid levels in patients with cerebrovascular disease.
  • To assess hemorheological changes in patients with transient ischemic attacks (TIAs), chronic unilateral cerebral infarctions (UCI), and cerebrovascular risk factors (RF).

Main Methods:

  • Whole blood viscosity (WBV), plasma viscosity (PV), hematocrit (Hct), fibrinogen (Fib), Cholesterol (Chol), triglycerides (Tg), and high-density lipoproteins (HDL) were measured.
  • Measurements were taken in 43 TIAs patients, 53 UCI patients, 57 RF patients, and 56 healthy controls.
  • Viscosity was assessed using Couette rotational and capillary viscometers.

Main Results:

  • Increased Hct, Fib, WBV, and PV were observed in TIAs and UCI patients, with more pronounced changes in UCI.
  • Elevated Hct and WBV were significant in the RF group.
  • Cholesterol and triglyceride levels were higher in UCI patients and the RF group, correlating significantly with PV in TIAs and RF groups.

Conclusions:

  • Plasma triglycerides play a significant role in reducing blood fluidity.
  • Elevated triglycerides contribute to impaired cerebral circulation in patients with cerebrovascular disease.
  • These findings underscore the importance of managing lipid profiles for cerebrovascular health.

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